Episode #139 Featuring Dr. Rafael Gonzalez!  A masterclass on the IMMUNE SYSTEM!  The Eye Opening Guide to EVERYTHING you need to know about the IMMUNE SYSTEM!

The Dylan Gemelli Podcast

Dr. Rafael Gonzalez discusses the immune system's critical role in health, aging, and disease prevention. He explains how modern lifestyle factors weaken immunity and increase risks of cancer, autoimmune disorders, and c

Key takeaways

• Immune health is central to all diseases

Transcript preview

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So claim your free aging muscle protocol guide and free sample of might appear gummies from timeline at timeline.com slash Dylan. It's the science back breakdown of exactly what's happening to your muscles as you age and how to fight back. All right everybody welcome back to the Dylan's Emily podcast. So you know one of the huge benefits that you get when you interview so many different people is that you get when you interview so many get introductions you really weren't ready for or weren't aware we're coming. And that's what happened with me and my guest today. I did several interviews there back and forth with Dr. Daniel Pompa and he said, well, I got a couple people I think are going to be of significant interest to you and I, of course, I'm going to take his recommendations. But this one in particular stood out to me of the ones that he sent me and I have been excited for this interview ever since we talked. And I think that you're going to see very quickly as to why. Now my guest today serves as the Chief Development and Science Officer for Restem Group and he has extensive knowledge in all aspects of cellular biology, regenerative medicine, and the key to longevity, maintaining immune health. And he has several patents and leads multiple clinical studies, which we're going to talk about today because he's got some new information that he wants to provide that I can't wait to hear about. And I specifically didn't have him tell me so I could learn right with you guys in the brand new. But he developed an immune-based. therapy using natural killer cells in the context of longevity and it demonstrated one of the first of its kind methods to reduce immunosinescence in humans and he's also produced a regenerative medicine exosome topical that's disrupted the cosmetic rejuvenation space so we're gonna get at all this and plenty more my friends welcome Dr Raphael Gonzalez. you do, especially when we talk about the most important thing in our body, the immune system. I am so stoked. You know, I've actually had some pretty strong discussions, Dr. Jeffrey Bland and I had a really good one on the immune system, Dr. William Lee, all highlighting the importance of it, and I know that you have an extreme expertise in that, and so my knowledge base is bigger than when you and I talked and I'm ready for you to enhance it to the highest extent. amongst everything else that you talk about. So once again, thanks for coming in here to see me. I really value anybody's time, especially yours because I know the extent of where we're going today. So let's lead into that with some of the discussion on the immune system, but you made it very clear in what you just said, the most important. Why do you say that? The main reason is because every single disease has an immune component to it. believe it or not and some people say out there well no if I have a genetic disease it does not know there's an immune component to the progression of that disease always is for a simple example of such is something such as pediatric duchen muscular dystrophy which is a devastating thing for pediatric kids it's awful yet if I can help control some of the immune destruction in there I can slow down the progression of that disease immune system is so powerful, there's every single disease. Neurological diseases, we take them for granted, it's mostly an immune system issue. The immune system has gone array, it's not doing what it's supposed to do, and it causes a neurological issue. Would you say that progressively over time that immune system health has declined? Significantly. Okay, and why would that be? One of the biggest burdens is a lot of things, number of, number, number, one is diet, what's going on what we're being fed or being dealt with on a daily basis. Two, the environment is really, really bad. And three, your immune system as you age every cell in your body ages, no matter what however you think about it. It's something called the hayflick limit. Every cell in your body has a finite amount of divisions and at some juncture it stops dividing and doesn't do much. This is the hayflick limit, but the biggest problem as you age and you can see this as you're developing is on a daily basis your immune system is challenged Well what happened six years ago six was a six seven it's been a long time now six years ago COVID right We got hit with another challenge to our immune system. Yes. Yes. Yes. And it was a devastating challenge to the immune system. about a lot of times is listen the UFC fighter is gonna beat a standard two three four people on the street but when seven eight ten people come at him he's not gonna win and it's what happens on a regular basis with your immune system it's it's it's really bad because you're challenged with daily bacteria you're challenged with daily mold toxins fungus microplastics which is a nightmare our nightmare, the environment, the pollutants, everything. Your immune system has to deal with that. And if your immune system gets overwhelmed, it's a big problem. The biggest issue we're having is we go back to the COVID is the virus. And a lot of people don't understand they think a bug is a bug is a bug. No. A virus is something that requires a host. And a lot of people don't understand they think a bug is a bug is a bug. No. A virus is a bug is a bug. No. A virus is something that requires a host. this alien has come into you and it's crazy if you look at images of it it looks like a little spaceship that basically shoots its DNA into your cells and then replicates and it lives there so this thing knows ways of since you require you're required for it to live in knows ways how to hide and how to cause havoc and if you're system is challenged or if you're dealing with eight ten other things this thing is going to be a massive burden like there's many diseases now and there's more and more evidence coming out especially autoimmune diseases which are becoming really problematic not only in the US but worldwide and more and more and more surfacing more individuals that think they only have rheumatore arthritis have an ancalosis spondylitis have ulcerative kaleidus have all these different autoimmune diseases have all these different autoimmune diseases sort of of combined in one. It's because the immune system has become somewhat hijacked in many instances and the hijacking many times are these viruses where we've finally identified at least one so far that is multiple sclerosis that is hijacked by Epstein-Barr virus is what causes it. So these viruses are or it's causing a lot of problems. Don't get me wrong, there are good viruses like there's good bacteria that we have to lift symbiotically with. majority of them specific ones are really bad and detrimental to our system. What's the direct cause to your cells that then in turn weakens the immune system? What ends up happening is the immune system, especially in the context of an autoimmune disease, it becomes exhausted. You know, cells divide and turnover on a regular basis. Right. Your body, especially when you have an autoimmune disease, your body has now saw something as it is foreign. You know, So if it sees something as foreign, it goes on to overdrive to attack that foreign entity. For instance, in a particular disease that we have a clinical study for, it's called polymyositis, dramatomyositis, myomitis, myomitis, myomitis, myomiaitis, myomitis, meaning muscle, muscle, it attacks skin. Eventually these patients will have issues with their lungs because they end up succor, and it sees your own skin, your own muscle is foreign, is foreign, is foreign, is foreign. It's killing it and it's on overdrive. It's not balanced It's not in what's called a regulatory state which is the way your immune system is supposed to be Our body's supposedly consistently in a regulated state Which is called homeostasis And we want to be in homeostasis when the immune system is consistently on overdrive and cells are dividing at some juncture we talked about the first thing we talked about earlier that hayflake limit the cells are no longer gonna be able to function correct And then the system says, well wait a second, how do I because your immune systems works in one particular way? It is attack, try to remove, try to eliminate, which is inflammation, and then to the opposite spectrum, which is called a TH1 inflammatory response, and then to the opposite spectrum it has to heal, which is a TH2 anti-inflammatory response. But if you have too much of this, which is that inflammatory response, this healing cannot respond. It can't do anything. The weird thing about the immune system is cancer. I was going to ask about that, but I'll let you go first. Is cancer. That cancer patient, completely opposite from that autoimmune patient, does not mount a killing response. That individual that has cancer we now know has a high amount of regulation, so there's no killing. That's one aspect of it besides the cancer's ability to hide. Right. It finds a way to hide, to get away from anything and to do it. But you don't have an appropriate mounting killing response. In those patients you normally have a healing response, but you can't heal anything without eliminating it. Could you just explain what causes cancer to start like cellularly how it actually begins? There's many well there's many different things that happen mostly mutations So if you think of on a daily basis You go outside and you're exposed to UV light and you most likely will get a mutation in your immune system the first responder to that believe it or not one of the first responders is called the natural killer cell It is supposed to target it is supposed to eliminate that immediately That's when your immune systems optimize if it is not if it is not then this thing goes unchecked. That unchecked has a possibility just in the context of let's say skin to go into the blood system. What people don't understand is that we're not quite there in the technology of the testing aspect. Somebody will go and they'll go get a full body scan. My body scan is completely clear. The problem is to you identify a million cells in a ball and being a cell cell biologists I see this is a spec on a table. There is no technology out there that's really going to identify that spec on the table. We have to talk about a billion cells in a ball which is the end of my fingertip which is not much. That's a problem. That's something that might be identifiable but even that's a little bit difficult to identify because when you talk about people have you know a millimeter you know that's what they normally catches a millimeter two millimeters you know centimeter is billions of cells and it's massive I know and then what people don't the other thing that we don't understand which now they're starting to get a little bit more progressive on the testing aspect of it is looking at those cells that are in like you find it in a legion or something like that those cells that are found have the propensity to release cells and these are called circulating tumor cells and those cells testing now that you can actually detect those, which people are now getting smarter, smarter with detections of it. That is the problem when you talk about somebody who's had cancer and you talk about more than anything else, no evidence of disease versus in remission of disease. You can't find disease versus in remission of disease. Because you don't really know and it's hard to detect if this stuff has been circulating and if it's going to come back. The key to all of this is maintaining immune health. Would you say, in all your... of understanding and observation and I think I know the answer but I want to know from you that a weakened immune system will make you more susceptible to developing cancer or cancerous cells. A thousand percent. Okay. All right. So that would that's why I wanted you to give the full explanation of how it caused and then relate it to the immune system in general. Yeah something in the body's gone array and the immune system hasn't detected it, hasn't killed it. The immune system is not working optimally. So if you were say around cancer causing aspects whether and people can argue what those are anymore but let's just say you're around heavy Heavy chemicals that would potentially cause cancer microplastics etc if you have a very strong immune system you have a far greater chance of not developing cancer as opposed to somebody that's got a weakened one or has kind of suffered some sort of some alterations with their immune system a thousand percent yep okay correct all right so it's it's a cellular but the immune system is going to play a huge role into preventing or at least mitigating the potential spread or growth of that. Yeah well the immune system is the one that's got to take care of the immune cells the immune system in general whether it's part of the innate the immediate response or the secondary response which is the military those have to be able to work together and eliminate and kill regulate and heal. They are the key to all aspects of longevity including believe it or not. your appearance is, whether you look healthy, you're not healthy, and it's an issue. And one of the things you have talked about, for instance, if you get burdened with a massive metal toxicity, what does the immune system have to do? The immune system has to now go and direct it towards that. Right. The entire immune system has to go, especially when you're older, has to go and direct it towards that. It doesn't even mount a correct short response like when you were young. But what happened to everything else that the other viruses and everything else. Now all of these things are opportunistic. That's where these things surface. The simplest example of this is when you look at chicken pox or when you look at basically, you know, the age associated aspects of chicken pox, which is shingles, is it's an opportunistic virus, your immune system becomes weakened or you have stress. Stress is a killer. Yeah. You get stress. It's an opportunistic virus. You get stress and the immune system becomes dampened, weakened, this now surfaces. Your immune system has to figure out how to remove it to clear it. When my dad passed away my mom got shingles and she got psoriasis and those are extremely stress-related problems. Right, okay and that weakens your immune system