The Smallest Molecule With Huge Potential... | Tyler W. LeBaron | DSH #2038

Digital Social Hour

This episode explores molecular hydrogen as a potential therapeutic agent, highlighting its unique properties, scientific research, and applications in health and wellness. Tyler W. LeBaron, founder of the Molecular Hydrogen Institute, discusses its role in reducing oxidative stress and supporting cellular function.

Key takeaways

• Molecular hydrogen is the smallest molecule, enabling easy diffusion into cells and tissues.
• It shows therapeutic potential across 200+ disease models with over 3,000 studies supporting its effects.
• Hydrogen gas is naturally produced by gut bacteria and linked to lower risks of metabolic and neurodegenerative diseases.

Transcript preview

Science is all about being self-correcting and changing its position to be in line with the evidence and being improving by friction, by people being curious and asking questions. Like, well then how do you explain this? How do you explain that? What about this? That's how science works. And that's the nice thing about molecular hydrogen is it is the smallest molecule, and so we can easily penetrate hydrogen gas because it's a neutral and non-polar molecule. It's easily able to diffuse right through the cell membrane and directly into directly into into into into into into the cell membrane and directly into into into into into into into into into into into into into into into into into into into into into the cell membrane. to say the model conjure which we have shown has really important effects. Okay guys here at Dave Vassfri's Biohacking Beyond Conference we got Tyler here we're gonna talk molecular hydrogen I've never had someone talk about this on the show so thanks for coming yeah my pleasure absolutely yeah fill everyone in because there's probably a lot of people watching this that don't even know what that is what it does not all that stuff yeah so hydrogen so hydrogen so pre-O-O-Table of elements, hydrogen is number one, right? And that hydrogen is just a proton and an electron. And, but with just a single electron, it's actually reactive. It's a free radical. So it's going to react with other atoms, other elements, very easily. So, for example, it can react with oxygen and can form water. That's where you have H2O. You have oxygen and two hygens combined to that, right? Or can react with carbon to form, like glucose, which is C6. That. That. That. That. That's, in. That's, in. That's, in, in. That's, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, in, glucose molecule. That hydrogen atom could react with nitrogen to form amino acids, ammonia, or it could react with another hydrogen atom to form a molecule of hydrogen. We call that molecular hydrogen, hydrogen gas. And that is the therapeutic molecule that I've been researching and I'm excited about. And I've been involved in this area, basically since 2009, so I'll, you know, around 16 years. And you're finally starting to see some success. Yeah, it's starting to take off, which is exciting. So I've always been involved in health and just my whole whole like hell-nunchie school right just for really loving this area and I learned about hydrogen gas around 2009 and started reading with the papers and then in 2013 for my biochemistry degree I went to Japan and I researched some of the molecular mechanisms of hydrogen on various cell celline pathways and we found you know it's actual effects in cell closer systems and of course animal studies and so on but it was really neat for me to see that with my own eyes and to meet other research and just to have that overall experience. And so then when I came back to America, I was passionate about this. Like, wow, this is something that's really neat, it's really picking up here in Japan. Nobody seems to know about it here in America. And also I realize that in Japan, there's also a lot of misunderstanding about hydrogen. People would conflate it with atomic hydrogen, right? Just that hydrogen atom or alkaline water or something that's totally not what's totally not what hydrogen. gas is about. And so I decided to start a website so I could educate people and bring the awareness about the potential of hydrogen gas, the therapeutic molecule and increased that research and so on. And I called that website the Molecular Hydrogen Institute. And that is now is a 501c3 science-based nonprofit, which I've been basically doing since 2013. It's focused on just that education and formed a collaboration with a lot of research groups, around the world and later did my master in the later PhD. My PhD was in animal physiology. Okay. And I did my dissertation on cardiovascular and superb vascular diseases and we used hydrogen gas as a therapeutic and we could see some pretty interesting effects. In animals. We actually did a couple ones but we did like in rats, radio protective effects like on the heart as well as in adult pigs. We did a heart simulated heart transplants. And we did a couple ones, but we did like in rats. gas had some benefits in that entire transplantation situation. Because it's a really difficult thing. You know, we talk about the heart being exposed to free radicals, inflammation, makes it the heart doesn't work as well. So being able to improve that process, increase survivability, it's really important. And hydrogen gas, being the smallest molecule in the universe, has that potential to really help with that. Interesting. So those are some of the studies that I was involved in with my PhD. There's a lot of research all over the world that's been researching this and there's, you know, the research is still growing, right? There's not, it's not FDA approved. There's still a lot of questions about how clinically effective it truly is, like when we really look at the hardcore science. But the therapeutic effects of hydrogen has been shown across 200 different human human and animal disease models with over 3,000 publications, 200 different human studies. I get pitched casinos constantly. I get pitched casinos constantly constantly. I get pitched casinos constantly. I get pitched casinos constantly constantly constantly constantly constantly constantly. I can constantly. I get. I get. I get. I get. I get. I get. I get. I get. I get. I get. I get. I get. 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Right and again a lot of these are you small maybe only a year long or maybe less than a hundred subjects or so but again this is good noise right I get a signal that's coming from from the noise and the preliminary evidence is important and I think it behooves us as researchers to investigate that signal that's coming from the noise and the preliminary evidence is important and I think it behooves us as researchers to investigate that more and determine how clinically relevant it really is and that's really what I'm passionate about. Nice. So are hospitals using hydrogen yet or? Not at this point. Not this is not FDA approved but you know in in Japan for example hydrogen gas was was given initial approval as an advanced medicine class 2B medicine for the purpose of doing clinical research and they did a major study in postcardiacore syndrome. And there was a 15 different hospitals that were set up to doing this study. And they found that those inhaling the hydrogen gas, basically they applied 2% hydrogen gas. So it was an inhalation of hydrogen gas. It was that compared to standard treatment alone. And those inhaling in the hydrogen gas, after three months, it looks at their survivability. That kind of people survived. And it was like a 39% increase. Just from inhaling at once? Yeah. Yeah. It was, it was, it was actually just a once. Yeah. Yeah. session. Holy cross. It was 18 hours. They came in comatose patients and there was like 39% increased survivability. That's insane. And then there was also improved neurological scores as well. I don't know. I don't think that would reach statistical significance yet. But that's largely because it was the sample size only 73. This happened during the COVID pandemic and so they actually had to truncate the study a little bit. But even the neurological scores. I mean it's the trend was extremely strong it's like, I don't, 30% or something, improved neurological function as well. That's impressive. And so... I might start taking it just for that reason alone because I make a living off my brain, so... Yeah, we do. And that's the nice thing about molecular hydrogen is it is the smallest molecule, and so we can easily penetrate the blood main barrier. No. When we're talking about improving the cellular function or whatever it is, we first have to get that molecule inside of us. And that's difficult for a lot of molecules because, for example, we have, we can use a vitamin C as an example. Vitamin C of course can go everywhere, but it takes time, it has to go through certain transporters. Vitamin C is water-soluble, and so it doesn't easily pass through the cell membrane. And so you actually have these protein channels that are required, like transporters that are able to transport vitamin C from the extulator space to the insulator space. And this takes time. and everything. So pretty much every drug and supplement, the hydrophilic ones anyways, they require these transporters, secondary or active transporters. Even water, water is just a small, simple molecule, right? It's neutral, but it is a polar molecule. Water does not just pass through the cell membrane. It has to go through these protein channels called an aquaporin. But hydrogen gas, because it's a neutral and non-polar molecule, it's easily able to diffuse right through the cell. membrane or the blood-brain barrier or the testis barrier anywhere and directly into say the model conjure which we have shown has really important effects. Nice. So you put the tablets right you're putting in water and then drinking it or? There's a couple ways to administer hydrogen gas. We can take the gas and dissolve it into water such as with the hydroproducing tablets those are on the market. We've done clinical research on that and other groups as well. But there's lots of ways to get hydrogen water water bottles and there's even like water bottles and there's even like water bottles and there's, ionized water. The problem with a lot of these methods is that a lot of times the hydrogen gas is not a very high concentration or not even therapeutically relevant or maybe the concentration decreases over time depending on how it's being used. So I know a lot of people prefer to use a tablet at least at least in research just because we know we're giving a high consistent dose of molecular hydrogen right. But the hydrogen water, that's one way is through hydrogen water but the other way is through inhalation of hydrogen gas. Those are two primary. ways and both of them have their own benefits because they have unique profile, pharmacokinetic profile to get the molecular hydrogen. I've recently now involved with inhalage 2, it's a hydrogen gas inhalation machine we developed, we can talk about that a little bit later, but that's for providing inhalation of hydrogen gas. And this is going to be really important for those who want to try hydrogen therapy through inhalation, the because it's like I said it's a different method to get it and we can create regulate the dose and make sure it's at a therapeutic level. Right. Can you get that hydrogen gas naturally in certain areas of the world or you can only get it through concentrated? Let me ask you something. When was the last time you truly relax? Not scrolling, not sleeping with your phone in your hand. I mean real mental recovery. That's why I've been using brain tap. It combines guided visualization, immersive sound and light-based brain-based brainwave entertainment, shift from stress mode to a more balanced state. 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You know it is interesting there are some natural places around the world where hygiene gas is present whether it's from like basalt catalyzed reactions and you know iron for example in fact it's believed that life started deep down like the deep sea hydrothermal vents there where hydrogen gas would be produced and hydrogen gas could act as an energy source and that's when your Arcaia your bacteria basically first started as a using hydrogen gas and energy source and then throughout time which the other cool thing so if we consider the hydrogen gas was basically the first sub-sub-subt present straight of life that got life to start. And it's also involved even the evolution of life. Like our modochondria are really similar to bacteria themselves. But there's this whole research on hydrogosomes and hydrogenases and the similarities to mitochondria and that hygiene gas seem to be really key in forging the separation between your prokaryotes and your eukaryotes, or like your bacteria and your plant and animal cells. similar proteins that are also involved. And so hydrogen gas actually been involved this entire time. And so go into your question, there are even these, there are still some places that today where there's hydrogen gas that can get these waters and so it's been proposed that maybe some of these waters that have had beneficial effects. If those are true, potentially is because of the dissolved heat gas on there. But even more, we have evolved to develop a symbiotic relationship with hydrogen-producing hydrogen-producing bacteria in our gut and it's very interesting that if you have a healthy microbiome and you have a healthy diet then you naturally produce lots of hydrogen gas. Interesting. And in fact there's a pretty interesting correlation between the more hydrogen gas you're producing you tend to have lower risks of metabolic syndrome or diabetes or dementia, Alzheimer's, in fact Japanese sense that are centenarians they have lower risk of metabolic syndrome or diabetes or dementia, Alzheimer's, in fact Japanese Japanese that are centenarians they have higher breath hydrogen gas production. And so there's something important about the microbiome. Of course this is different than say people with Cebo or something small intestinal bacterial overgrowth because that's overgrowth in the small intestines. But just that hydrogen gas is a commonly produced molecule like I said from the bacteria and almost already produces hydrogen gas but not as much as much as many of our ancestors did just because they don't have as much of that hydrogen-producing bacteria and they're not getting near as much fiber as they used to back in the day. But we see again from these studies like even if we look at the Proxins of those patients and their studies published showing that they tend to have less hydrogen producing bacteria in their bodies and then their gut than those who don't have Proctanesome disease. So this is again this is just a correlation. A correlation does not equal calcation of course. But it's an important correlation because it suggests that a signal could be there because it's all in the right direction. So then we do these you know, and we can see administration of molecular hydrogen and see therapeutic benefits. It starts to make sense that. Control study, yeah. When you were in Japan did you meet any centenarians out there? I